In early 2019, The Alzenia Project founder Cynthia R. Plouché, decided to host a luncheon for a group of her college classmates on the occasion of their 40th reunion. The reunion luncheon turned out to be an opportunity to not only renew friendships and bring each other up to date on their lives post-college but it became the spark that ignited Cynthia to create the Sisterhood of Radcliffe podcast with the support of Byron Hunter, a documentarian and Cynthia's childhood friend.